Journal article
Membrane potassium currents in human radial artery and their regulation by nitric oxide donor
Abstract
OBJECTIVE: The human radial artery has demonstrated superior long-term results as a graft in coronary bypass surgery, but undesirable post-surgical spasm limits its clinical application. Few have examined its excitatory properties, especially the underlying ion channel mechanisms. In this study, we investigated the kinetic and pharmacological properties of the smooth muscle membrane potassium currents of this important artery.
METHODS AND …
Authors
Zhang Y; Tazzeo T; Chu V; Janssen LJ
Journal
Cardiovascular Research, Vol. 71, No. 2, pp. 383–392
Publisher
Oxford University Press (OUP)
Publication Date
July 15, 2006
DOI
10.1016/j.cardiores.2006.04.002
ISSN
0008-6363
Fields of Research (FoR)
Medical Subject Headings (MeSH)
4-AminopyridineAdultAgedAged, 80 and overBlotting, WesternFemaleGlyburideGuanylate CyclaseHumansIn Vitro TechniquesIon Channel GatingMaleMembrane PotentialsMiddle AgedMuscle, Smooth, VascularMyocytes, Smooth MuscleNitric Oxide DonorsOxadiazolesPatch-Clamp TechniquesPenicillaminePeptidesPotassium Channel BlockersPotassium ChannelsPotassium Channels, Calcium-ActivatedPotassium Channels, Voltage-GatedQuinoxalinesRadial ArteryTetraethylammonium Compounds