Journal article
Reversal of New, Factor-specific Oral Anticoagulants by rFVIIa, Prothrombin Complex Concentrate and Activated Prothrombin Complex Concentrate: A Review of Animal and Human Studies
Abstract
INTRODUCTION: Recombinant activated factor VII (rFVIIa), prothrombin complex concentrate (PCC) and activated PCC (aPCC) are three non-specific haemostatic agents sometimes employed to reverse new, factor-specific oral anticoagulants.
METHODS: We conducted a review in the literature to compare the abilities of rFVIIa, PCC and aPCC to reverse factor-specific anticoagulants. MEDLINE and EMBASE databases were searched up to Oct 2013.
Authors
Lee FMH; Chan AKC; Lau KK; Chan HH
Journal
Thrombosis Research, Vol. 133, No. 5, pp. 705–713
Publisher
Elsevier
Publication Date
May 2014
DOI
10.1016/j.thromres.2014.01.031
ISSN
0049-3848