Journal article
Ginger attenuates acetylcholine-induced contraction and Ca2+ signalling in murine airway smooth muscle cells
Abstract
Asthma is a chronic disease characterized by inflammation and hypersensitivity of airway smooth muscle cells (ASMCs) to different spasmogens. The past decade has seen increased use of herbal treatments for many chronic illnesses. Ginger (Zingiber officinale) is a common food plant that has been used for centuries in treating respiratory illnesses. In this study, we report the effect of its 70% aqueous methanolic crude extract (Zo.Cr) on …
Authors
Ghayur MN; Gilani AH; Janssen LJ
Journal
Canadian Journal of Physiology and Pharmacology, Vol. 86, No. 5, pp. 264–271
Publisher
Canadian Science Publishing
Publication Date
May 2008
DOI
10.1139/y08-030
ISSN
0008-4212
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AcetylcholineAnimalsBronchoconstrictor AgentsBronchodilator AgentsCalcium Channel BlockersCalcium SignalingDose-Response Relationship, DrugFemaleZingiber officinaleLungMiceMice, Inbred BALB CMicroscopy, ConfocalMuscle ContractionMyocytes, Smooth MusclePlant ExtractsPlant RootsTissue Culture TechniquesVerapamil