Journal article
Neutralizing Antibodies Against Previously Encountered Influenza Virus Strains Increase over Time: A Longitudinal Analysis
Abstract
Antigenic diversity shapes immunity in distinct and unexpected ways. This is particularly true of the humoral response generated against influenza A viruses. Although it is known that immunological memory developed against previously encountered influenza A virus strains affects the outcome of subsequent infections, exactly how sequential exposures to antigenically variant viruses shape the humoral immune response in humans remains poorly …
Authors
Miller MS; Gardner TJ; Krammer F; Aguado LC; Tortorella D; Basler CF; Palese P
Journal
Science Translational Medicine, Vol. 5, No. 198,
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
August 14, 2013
DOI
10.1126/scitranslmed.3006637
ISSN
1946-6234