Journal article
Influenza A Virus Specific T Cell Immunity in Humans during Aging
Abstract
To study the decreasing responsiveness of the immune system during aging, influenza virus specific cellular immunity was investigated in a cohort of healthy blood donors between 18 and 70 years of age. The percentage of influenza A virus specific T cells was determined by flow cytometry and found not to change during aging. After stimulation with phorbol 12-myristate 13-acetate and ionomycin, an increase in the percentage of IFN-gamma and IL-4 …
Authors
Boon ACM; Fringuelli E; Graus YMF; Fouchier RAM; Sintnicolaas K; Iorio AM; Rimmelzwaan GF; Osterhaus ADME
Journal
Virology, Vol. 299, No. 1, pp. 100–108
Publisher
Elsevier
Publication Date
July 2002
DOI
10.1006/viro.2002.1491
ISSN
0042-6822