Journal article
IL-27p28 specifically regulates MHC II expression in macrophages through CIITA
Abstract
Antigen-presenting cells (APCs) constantly express major histocompatibility complex II (MHC II), including macrophages and dendritic cells (DCs) which deliver antigens to CD4+ T cells and play an important role in adaptive immunity. The expression of MHC II is controlled by the transcriptional coactivator CIITA. Interleukin-27 (IL-27), a newly discovered IL-12 family cytokine, is composed of p28 and EBI3 subunits. In this study, we used …
Authors
Han Y; Zhang X; Wang Q; Cui X; Wang H; Zhang X; Wang Q; Ji J; Wang Y; Wang S
Journal
Immunobiology, Vol. 228, No. 6,
Publisher
Elsevier
Publication Date
11 2023
DOI
10.1016/j.imbio.2023.152757
ISSN
0171-2985