Journal article
Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score
Abstract
Importance: Acute dysfunction of vital organs is the hallmark of critical illness. The Sequential Organ Failure Assessment (SOFA) score, the most widely adopted approach to describe organ dysfunction, has not been updated in 30 years and therefore may not appropriately capture current clinical practice and outcomes.
Objectives: To inform the data-driven component of an updated score (SOFA-2) in varied geographical and resource settings (stages …
Authors
Ranzani OT; Singer M; Salluh JIF; Shankar-Hari M; Pilcher D; Berger-Estilita J; Coopersmith CM; Juffermans NP; Laffey J; Reinikainen M
Journal
JAMA: The Journal of the American Medical Association, Vol. 334, No. 23,
Publisher
American Medical Association (AMA)
Publication Date
October 29, 2025
DOI
10.1001/jama.2025.20516
ISSN
0098-7484