Comparative Efficacy of Advanced Therapies for Management of Moderate-to-Severe Crohn’s Disease: 2025 AGA Evidence Synthesis

Abstract

BACKGROUND & AIMS: We performed an updated systematic review and network meta-analysis to inform the 2025 American Gastroenterological Association Clinical Guidelines on the management of moderate-to-severe Crohn's disease (CD). METHODS: We searched multiple electronic databases from inception through August 14, 2024, to identify randomized controlled trials in adults with moderate-to-severe CD, comparing advanced therapies (eg, tumor necrosis …

Authors

Singh S; Murad MH; Yuan Y; Ananthakrishnan AN; Click B; Syal G; Haydek JP; Agrawal M; Kappelman MD; Lewis JD

Journal

Gastroenterology, Vol. 169, No. 7, pp. 1516–1536

Publisher

Elsevier

Publication Date

12 2025

DOI

10.1053/j.gastro.2025.08.032

ISSN

0016-5085

Associated Experts

Yuhong Yuan

Assistant Professor (Part-Time), Faculty of Health Sciences

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