Journal article
CRISPR screen reveals SOX2 as a critical regulator of CD133 and cellular stress response in glioblastoma
Abstract
Glioblastoma (GBM) remains a formidable challenge in clinical settings due to limited treatments available. The surface protein CD133 marks glioblastoma stem cells (GSCs), cells capable of overcoming therapeutic pressures and correlate with more aggressiveness tumor phenotypes. In this study, we employed a CRISPR-Cas9 functional screen to deconvolute CD133 dynamics in tumors. This led us to establish that SOX2 is a key player in controlling the …
Authors
Savage N; Danis E; Chokshi CR; Custers S; Shaikh MV; Miletic P; Venugopal C; Brown KR; Vibhakar R; Moffat J
Journal
Scientific Reports, Vol. 15, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41598-025-20183-7
ISSN
2045-2322