Journal article
Biological sex impacts immune cell proportions and epigenetic profiles in the developing pediatric immune system
Abstract
Age- and sex-related differences in immune cell compositions and immune outcomes have been identified across the life course, but a comprehensive and nuanced characterization of these changes during the rapid developmental window of early life is lacking. We explore immune associated DNA methylation (DNAm) changes in the context of age and sex leveraging whole blood samples collected at ages one and five from CHILD, a Canadian longitudinal …
Authors
Edwards K; Merrill SM; Konwar C; Jude MS; Zhuang BC; Meijer M; Navarro-Delgado E; MacIsaac JL; Mandhane P; Simons E
Journal
Communications Biology, Vol. 8, No. 1,
Publisher
Springer Nature
DOI
10.1038/s42003-025-08844-9
ISSN
2399-3642