Journal article
Leveraging Medulloblastoma Clonal Dynamics to Overcome Treatment Resistance.
Abstract
PURPOSE: Medulloblastoma (MB) is a common pediatric brain tumor with distinct molecular subgroups, of which, Group 3 MB is associated with increased recurrence, metastatic potential and poor patient outcomes. Small molecule inhibitors targeting BMI1 have been shown to be efficacious against several types of malignant tumors, including pediatric MB. While our previously published in vivo study provides a promising proof-of-concept for the …
Authors
Bakhshinyan D; Custers S; Escudero L; Suk Y; Brown KR; Patel H; Adile AA; Chokshi C; Shaikh MV; McKenna D
Journal
Clinical Cancer Research, , ,
Publisher
American Association for Cancer Research (AACR)
Publication Date
October 15, 2025
DOI
10.1158/1078-0432.ccr-24-4010
ISSN
1078-0432