Journal article
Leveraging Medulloblastoma Clonal Dynamics to Overcome Treatment Resistance.
Abstract
PURPOSE: Medulloblastoma is a common pediatric brain tumor with distinct molecular subgroups. Among them, group 3 medulloblastoma is associated with increased recurrence, metastatic potential, and poor patient outcomes. Small-molecule inhibitors targeting B cell-specific Moloney murine leukemia virus insertion site 1 (BMI1) have demonstrated efficacy against several types of malignant tumors, including pediatric medulloblastoma. Although our …
Authors
Bakhshinyan D; Custers S; Escudero L; Suk Y; Brown KR; Patel H; Adile AA; Chokshi C; Shaikh MV; McKenna D
Journal
Clinical Cancer Research, Vol. 32, No. 1, pp. 203–213
Publisher
American Association for Cancer Research (AACR)
Publication Date
January 6, 2026
DOI
10.1158/1078-0432.ccr-24-4010
ISSN
1078-0432