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7-OR: The Libre Enabled Reduction of A1C through...
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7-OR: The Libre Enabled Reduction of A1C through Effective Eating and Exercise Study—LIBERATE CANADA

Abstract

Introduction and Objective: Initiating and maintaining new eating and exercise behaviours with meaningful glycemic improvement is often difficult for those living with T2D. The LIBERATE study aimed to evaluate the efficacy of a real world, standardized, six-month, virtual group diabetes self-management education (DSME) program, which incorporated wearable technology including isCGM to support behaviour change. Methods: Participants with T2D and HbA1c ≥ 8% were recruited for this open label, prospective cohort study. The LIBERATE intervention included virtual small group sessions every two weeks for the first 12 weeks and monthly for the last 12 weeks. Participants used the FreeStyle® Libre 2 for glucose monitoring continuously during the first three months and had the option to use three sensors in the last three months. The FitBit Inspire 2 was used to track physical activity. Virtual group sessions were facilitated by a CDE with content created based on current DSME principles emphasizing the use of isCGM data to personalize lifestyle choices. The primary outcome was percent mean change in HbA1c. Paired T-tests were utilized for analysis. Results: In 92 participants (mean age, 55 years; 44% female; diabetes duration, 8 years; 78% not using insulin. HbA1c significantly improved from 9.8% (± 1.5%) to 7.6% (± 1.2%), p<0.01 at endpoint. Percentage mean time in range (TIR) (3.9mmol to 10.0mmol) also increased significantly; mean TIR at baseline = 66.8% (± 26.2%) vs. TIR at midpoint = 74.1% (± 24.5), p<0.05. Conclusion: Combining six months of virtual group coaching designed to empower individual self-management with isCGM technology rapidly improved HbA1c and TIR, with sustained effects seen at six months despite less intensive coaching. These findings support broader implementation of combining wearable technology and virtually supported DSME to enhance diabetes care and patient outcomes, including for those not yet on insulin therapy in T2D. Disclosure S.M. Reichert: Research Support; Abbott Diagnostics. Speaker's Bureau; Abbott. Advisory Panel; Novo Nordisk. Speaker's Bureau; Novo Nordisk. Other Relationship; Novartis Pharmaceuticals Corporation. Advisory Panel; Bausch Health, Sanofi, embecta, Eisai, Eli Lilly and Company. Consultant; Center for Effective Practice (CEP),. Research Support; Western University. Other Relationship; Diabetes Canada. Advisory Panel; Bayer Pharmaceuticals, Inc. Speaker's Bureau; Humber River Health, Federation of Canadian Medical Women, Medscape, Peer Voice. H.C. Gerstein: Advisory Panel; Abbott, Bayer Pharmaceuticals, Inc, Eli Lilly and Company, Novo Nordisk. Consultant; Pfizer Inc, Sanofi, Hanmi Pharm. Co., Ltd. Research Support; Eli Lilly and Company, Novo Nordisk, Hanmi Pharm. Co., Ltd. Other Relationship; Eli Lilly and Company, Novo Nordisk, Sanofi, Boehringer-Ingelheim, Abbott, Jiangsu Hansen, Zuellig Pharma, AstraZeneca. B. Harvey: None. A.G. Mikalachki: None. D. Sherifali: None. M. Mitchell: None. P. Brauer: None. D. Henke: None. L. Vancer: Speaker's Bureau; Abbott. S.B. Harris: Advisory Panel; Abbott. Consultant; Abbott. Research Support; Boehringer-Ingelheim. Advisory Panel; Dexcom, Inc. Consultant; Dexcom, Inc. Research Support; Canadian Institutes of Health Research. Advisory Panel; Eli Lilly and Company. Research Support; Eli Lilly and Company. Consultant; Medscape. Advisory Panel; Novo Nordisk. Research Support; Novo Nordisk, Novartis Pharmaceuticals Corporation. Advisory Panel; Sanofi. Consultant; Sanofi. Funding Abbott

Authors

REICHERT SM; GERSTEIN HC; HARVEY B; MIKALACHKI AG; SHERIFALI D; MITCHELL M; BRAUER P; HENKE D; VANCER L; HARRIS SB

Volume

74

Publisher

American Diabetes Association

Publication Date

June 20, 2025

DOI

10.2337/db25-7-or

Conference proceedings

Diabetes

Issue

Supplement_1

ISSN

0012-1797

Labels

Sustainable Development Goals (SDG)

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