Journal article
Antagonists of the Calcium Receptor I. Amino Alcohol-Based Parathyroid Hormone Secretagogues
Abstract
Functional screening of the former SmithKline Beecham compound collection against the human calcium receptor (CaR) resulted in the identification of the amino alcohol-based hit 2 (IC(50) = 11 microM). Structure-activity studies of 2 focused on the optimization of the right- and left-hand side aromatic moieties as well as the amino alcohol linker region. Critical to the optimization of this antagonist template was the discovery that the …
Authors
Marquis RW; Lago AM; Callahan JF; Trout REL; Gowen M; DelMar EG; Van Wagenen BC; Logan S; Shimizu S; Fox J
Journal
Journal of Medicinal Chemistry, Vol. 52, No. 13, pp. 3982–3993
Publisher
American Chemical Society (ACS)
Publication Date
July 9, 2009
DOI
10.1021/jm900364m
ISSN
0022-2623