Journal article
The Spindle Assembly Checkpoint Safeguards Genomic Integrity of Skeletal Muscle Satellite Cells
Abstract
To ensure accurate genomic segregation, cells evolved the spindle assembly checkpoint (SAC), whose role in adult stem cells remains unknown. Inducible perturbation of a SAC kinase, Mps1, and its downstream effector, Mad2, in skeletal muscle stem cells shows the SAC to be critical for normal muscle growth, repair, and self-renewal of the stem cell pool. SAC-deficient muscle stem cells arrest in G1 phase of the cell cycle with elevated …
Authors
Kollu S; Abou-Khalil R; Shen C; Brack AS
Journal
Stem Cell Reports, Vol. 4, No. 6, pp. 1061–1074
Publisher
Elsevier
Publication Date
6 2015
DOI
10.1016/j.stemcr.2015.04.006
ISSN
2213-6711
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AneuploidyAnimalsCell DifferentiationCells, CulturedCyclin-Dependent Kinase Inhibitor p21G1 Phase Cell Cycle CheckpointsIn Situ Hybridization, FluorescenceKinetochoresMad2 ProteinsMiceMice, Inbred C57BLMice, TransgenicMicroscopy, FluorescenceMitosisMuscle, SkeletalMyoblastsNocodazolePhenotypeProtein BindingProtein Serine-Threonine KinasesRegenerationSatellite Cells, Skeletal MuscleSpindle Apparatus