Antihypertensive Medication Timing and Cardiovascular Events and Death

Importance: Whether administration of blood pressure medications at bedtime instead of in the morning reduces cardiovascular risk is unknown, as findings from large clinical trials have not been consistent. There is also concern that bedtime antihypertensive use could induce glaucoma-related visual loss or other hypotensive/ischemic adverse effects. Objective: To determine the effect of bedtime vs morning administration of antihypertensive …