Journal article
GDF15 links adipose tissue lipolysis with anxiety
Abstract
Psychological stress changes both behaviour and metabolism to protect organisms. Adrenaline is an important driver of this response. Anxiety correlates with circulating free fatty acid levels and can be alleviated by a peripherally restricted β-blocker, suggesting a peripheral signal linking metabolism with behaviour. Here we show that adrenaline, the β3 agonist CL316,243 and acute restraint stress induce growth differentiation factor 15 …
Authors
Townsend LK; Wang D; Knuth CM; Fayyazi R; Mohammad A; Becker LJ; Tsakiridis EE; Desjardins EM; Patel Z; Valvano CM
Journal
Nature Metabolism, Vol. 7, No. 5, pp. 1004–1017
Publisher
Springer Nature
Publication Date
May 2025
DOI
10.1038/s42255-025-01264-3
ISSN
2522-5812