Journal article
Cryo-EM analyses unveil details of mechanism and targocil-II mediated inhibition of S. aureus WTA transporter TarGH
Abstract
Wall teichoic acid (WTA) is a polyol phosphate polymer that covalently decorates peptidoglycan of gram-positive bacteria, including Staphylococcus aureus. Central to WTA biosynthesis is flipping of lipid-linked precursors across the cell membrane by TarGH, a type V ABC transporter. Here, we present cryo-EM structures of S. aureus TarGH in the presence of targocil-II, a promising small-molecule lead with β-lactam antibiotic synergistic action. …
Authors
Li FKK; Peters SC; Worrall LJ; Sun T; Hu J; Vuckovic M; Farha M; Palacios A; Caveney NA; Brown ED
Journal
Nature Communications, Vol. 16, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41467-025-58202-w
ISSN
2041-1723