Journal article
Association between Locoregional Failure and NFE2L2/KEAP1/CUL3 Mutations in NRG/RTOG 9512: A Randomized Trial of Radiation Fractionation in T2N0 Glottic Cancer.
Abstract
PURPOSE: NFE2L2/KEAP1/CUL3 mutations have been validated for radioresistance in cell-based assays and animal models. However, clinical validation of these biomarkers has been challenging because of multimodality treatment regimens. This study aims to investigate the association between NFE2L2/KEAP1/CUL3 mutations and patient outcomes, including local failure, locoregional failure, disease-free survival (DFS), and overall survival, using samples …
Authors
Guan L; Torres-Saavedra PA; Zhao X; Major MB; Holmes BJ; Nguyen NK; Kumaravelu P; Hodge T; Diehn M; Zevallos J
Journal
Clinical Cancer Research, Vol. 31, No. 9, pp. 1615–1624
Publisher
American Association for Cancer Research (AACR)
Publication Date
May 1, 2025
DOI
10.1158/1078-0432.ccr-24-2334
ISSN
1078-0432