Journal article
No association between markers of systemic inflammation and endothelial dysfunction with Alzheimer’s disease progression: a longitudinal study
Abstract
IntroductionSystemic inflammation and endothelial dysfunction are potentially modifiable factors implicated in Alzheimer’s disease (AD), which offer potential therapeutic targets to slow disease progression.MethodsWe investigated the relationship between baseline circulating levels of inflammatory (TNF-α, IL-1ß) and endothelial cell markers (VCAM-1, ICAM-1, E-selectin) and 18-month cognitive decline (ADAS-cog12) in 266 mild-to-moderate AD …
Authors
van Setten A; Uleman JF; Melis RJF; Lawlor B; Riksen NP; Claassen JAHR; de Heus RAA
Journal
GeroScience, Vol. 47, No. 1, pp. 1093–1104
Publisher
Springer Nature
Publication Date
February 2025
DOI
10.1007/s11357-024-01294-x
ISSN
2509-2715