Journal article
COVID‐19 severity gradient differentially dysregulates clinically relevant drug processing genes in nasopharyngeal swab samples
Abstract
AIM: Understanding how COVID-19 impacts the expression of clinically relevant drug metabolizing enzymes and membrane transporters (DMETs) is vital for addressing potential safety and efficacy concerns related to systemic and peripheral drug concentrations. This study investigates the impact of COVID-19 severity on DMETs expression and the underlying mechanisms to inform the design of precise clinical dosing regimens for affected patients.
Authors
Nwabufo CK; Luc J; McGeer A; Hirota JA; Mubareka S; Doxey AC; Moraes TJ
Journal
British Journal of Clinical Pharmacology, Vol. 90, No. 9, pp. 2137–2158
Publisher
Wiley
Publication Date
September 2024
DOI
10.1111/bcp.16124
ISSN
0306-5251