Journal article
Targeting bacterial nickel transport with aspergillomarasmine A suppresses virulence-associated Ni-dependent enzymes
Abstract
Microbial Ni2+ homeostasis underpins the virulence of several clinical pathogens. Ni2+ is an essential cofactor in urease and [NiFe]-hydrogenases involved in colonization and persistence. Many microbes produce metallophores to sequester metals necessary for their metabolism and starve competing neighboring organisms. The fungal metallophore aspergillomarasmine A (AMA) shows narrow specificity for Zn2+, Ni2+, and Co2+. Here, we show that this …
Authors
Sychantha D; Chen X; Koteva K; Prehna G; Wright GD
Journal
Nature Communications, Vol. 15, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41467-024-48232-1
ISSN
2041-1723