Urinary thromboxane and risk of cardiovascular events: role of aspirin

Graphical Abstract The ASCEND substudy: a summary of results of the observational association between U-TXM and clinical outcomes, and the randomized comparison of aspirin and placebo on U-TXM and clinical outcomes. Observational findings showed positive correlations between U-TXM and SVE-R, and U-TXM and major bleeding. In the randomized comparisons, patients were assigned to aspirin or placebo. Aspirin treatment blocks TXA2 synthesis and …