Journal article
Impact of age on the host response to sepsis in a murine model of fecal-induced peritonitis
Abstract
IntroductionDespite older adults being more vulnerable to sepsis, most preclinical research on sepsis has been conducted using young animals. This results in decreased scientific validity since age is an independent predictor of poor outcome. In this study, we explored the impact of aging on the host response to sepsis using the fecal-induced peritonitis (FIP) model developed by the National Preclinical Sepsis Platform (NPSP).MethodsC57BL/6 …
Authors
Sharma N; Chen A; Heinen L; Liu R; Dwivedi DJ; Zhou J; Lalu MM; Mendelson AA; McDonald B; Kretz CA
Journal
Intensive Care Medicine Experimental, Vol. 12, No. 1,
Publisher
Springer Nature
DOI
10.1186/s40635-024-00609-8
ISSN
2197-425X