Conference
Abstract P3001: Regulation Of Perivascular Adipose Tissue By Follistatin In Hypertension
Abstract
Follistatin lowers BP and improves resistance artery health in spontaneously hypertensive rats (SHR), a model of essential HTN. Functionally, follistatin improves smooth muscle contraction and endothelium-dependent relaxation. Structurally, increased medial collagen was inhibited. Vascular ROS were also reduced. Perivascular adipose tissue (PVAT) regulates vascular tone via release of vasoactive substances. Oxidative stress in PVAT, as in HTN, …
Authors
Kuganathan A; Leal M; Lu V; MacDonald M; Gao B; Dickhout J; Krepinsky J
Volume
133
Publisher
Wolters Kluwer
Publication Date
August 4, 2023
DOI
10.1161/res.133.suppl_1.p3001
Conference proceedings
Circulation Research
Issue
Suppl_1
ISSN
0009-7330