Journal article
ID4-dependent secretion of VEGFA enhances the invasion capability of breast cancer cells and activates YAP/TAZ via integrin β3-VEGFR2 interaction
Abstract
Understanding the mechanisms of breast cancer cell communication underlying cell spreading and metastasis formation is fundamental for developing new therapies. ID4 is a proto-oncogene overexpressed in the basal-like subtype of triple-negative breast cancer (TNBC), where it promotes angiogenesis, cancer stem cells, and BRACA1 misfunction. Here, we show that ID4 expression in BC cells correlates with the activation of motility pathways and …
Authors
Benedetti A; Turco C; Gallo E; Daralioti T; Sacconi A; Pulito C; Donzelli S; Tito C; Dragonetti M; Perracchio L
Journal
Cell Death & Disease, Vol. 15, No. 2,
Publisher
Springer Nature
DOI
10.1038/s41419-024-06491-2
ISSN
2041-4889