Journal article
Feasibility of real time next generation sequencing of cancer genes linked to drug response: Results from a clinical trial
Abstract
The successes of targeted drugs with companion predictive biomarkers and the technological advances in gene sequencing have generated enthusiasm for evaluating personalized cancer medicine strategies using genomic profiling. We assessed the feasibility of incorporating real-time analysis of somatic mutations within exons of 19 genes into patient management. Blood, tumor biopsy and archived tumor samples were collected from 50 patients recruited …
Authors
Tran B; Brown AMK; Bedard PL; Winquist E; Goss GD; Hotte SJ; Welch SA; Hirte HW; Zhang T; Stein LD
Journal
International Journal of Cancer, Vol. 132, No. 7, pp. 1547–1555
Publisher
Wiley
Publication Date
April 2013
DOI
10.1002/ijc.27817
ISSN
0020-7136