Journal article
Efficacy and Safety of IL-12/23 and IL-23 Inhibitors for Crohn’s Disease: Systematic Review and Meta-Analysis
Abstract
BackgroundTargeting interleukin-23 (IL-23) is an important therapeutic strategy for Crohn’s disease (CD).AimsThis systematic review and meta-analysis assessed the efficacy and safety of selective IL-23p19 and IL-12/23p40 inhibitors in patients with moderate-to-severe CD.MethodsMEDLINE, Embase, and the Cochrane library (CENTRAL) were searched from inception to May 24, 2023, for randomized, placebo- or active comparator-controlled induction …
Authors
Vuyyuru SK; Solitano V; Hogan M; MacDonald JK; Zayadi A; Parker CE; Sands BE; Panaccione R; Narula N; Feagan BG
Journal
Digestive Diseases and Sciences, Vol. 68, No. 9, pp. 3702–3713
Publisher
Springer Nature
Publication Date
September 2023
DOI
10.1007/s10620-023-08014-z
ISSN
0163-2116