Predictive Accuracy of Traditional Methods to Assess Left Ventricular Stiffness in a Porcine Model of Heart Failure with Preserved Ejection Fraction

Objective: Left ventricular (LV) stiffening is a key pathophysiological component of heart failure with preserved ejection fraction (HFpEF) and contributes to pulmonary congestion and exertional dyspnea. Accurate assessment of LV stiffness is commonly accomplished via construction of end-diastolic pressure-volume relationships (EDPVRs) during transient reductions in venous return (i.e., preload). However, the extent to which this method …