Preprint
Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization
Abstract
Abstract The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization (QRS duration) and repolarization (JT interval). Abnormalities of the QT interval are associated with potentially fatal ventricular arrhythmia. We conducted genome-wide multi-ancestry analyses in >250,000 individuals and identified 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific …
Authors
Young WJ; Lahrouchi N; Isaacs A; Duong T; Foco L; Ahmed F; Brody JA; Salman R; Noordam R; Benjamins J-W
DOI
10.1101/2021.11.04.21265866
Preprint server
medRxiv