Preprint
IgA Potentiates NETosis in Response to Viral Infection
Abstract
ABSTRACT IgA is the second most abundant antibody present in circulation and is enriched at mucosal surfaces. As such, IgA plays a key role in protection against a variety of mucosal pathogens, including viruses. In addition to neutralizing viruses directly, IgA can also stimulate Fc-dependent effector functions via engagement of Fc alpha receptors (FcαRI) expressed on the surface of certain immune effector cells. Neutrophils are the most …
Authors
Stacey HD; Golubeva D; Posca A; Ang JC; Novakowski KE; Zahoor MA; Kaushic C; Cairns E; Bowdish DME; Mullarkey CE
DOI
10.1101/2021.01.04.424830
Preprint server
bioRxiv