Inducing Microscale Structural Order in Phage Nanofilament Hydrogels via Macromolecular Crowding with Globular Proteins

Biological hydrogels play important physiological roles in the body. These hydrogels often contain ordered subdomains that provide mechanical toughness and other tissue-specific functionality. Filamentous bacteriophages are nanofilaments with a high aspect ratio that can self-assemble into liquid crystalline domains that could be designed to mimic ordered biological hydrogels and can thus find application in biomedical engineering. We have …