IGF-I/BP-3 ADMINISTRATION PRESERVES HEPATIC HOMEOSTASIS AFTER THERMAL INJURY WHICH IS ASSOCIATED WITH INCREASES IN NO AND HEPATIC NF-κB

After a severe trauma, such as a cutaneous thermal injury, an increase in hepatocyte apoptosis has been associated with hepatocyte damage and impairment in hepatic function. Insulinlike growth factor-I (IGF-I) exerts antiapoptotic effects in several organs, thus improving organ homeostasis. The purpose of the present study was to determine whether IGF-I in combination with its principle binding protein-3 (BP-3) attenuates liver damage after a …