Journal article
The structure and composition of liposomes can affect skin regeneration, morphology and growth factor expression in acute wounds
Abstract
Liposomal gene transfer is an effective therapeutic approach to improve dermal and epidermal regeneration. The purpose of the present study was to define whether the biological or chemical structure of a liposome influences cellular and biological regeneration in the skin, and to determine by which mechanisms possible changes occur. Rats were inflicted a full-excision acute wound and divided into three groups to receive weekly subcutaneous …
Authors
Jeschke MG; Sandmann G; Finnerty CC; Herndon DN; Pereira CT; Schubert T; Klein D
Journal
Gene Therapy, Vol. 12, No. 23, pp. 1718–1724
Publisher
Springer Nature
Publication Date
December 1, 2005
DOI
10.1038/sj.gt.3302582
ISSN
0969-7128
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsApoptosisCell ProliferationCholesterolCollagenEpithelial CellsFatty Acids, MonounsaturatedFibroblast Growth Factor 7Gene Transfer TechniquesGenetic TherapyGrowth SubstancesInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor ILipidsLiposomesMaleMolecular WeightNeovascularization, PhysiologicPlatelet-Derived Growth FactorProtein ConformationQuaternary Ammonium CompoundsRatsRats, Sprague-DawleyVascular Endothelial Growth Factor AWound HealingWounds and Injuries