Journal article
Epidermal Growth Factor–Like Domain 7 Is a Novel Inhibitor of Neutrophil Adhesion to Coronary Artery Endothelial Cells Injured by Calcineurin Inhibition
Abstract
BACKGROUND: We investigated the effect of epidermal growth factor-like domain 7 (Egfl7) on nuclear factor-κB activation, intercellular adhesion molecule-1 expression, and neutrophil adhesion to human coronary artery endothelial cells after calcineurin-inhibition-induced injury.
METHODS AND RESULTS: Human coronary endothelial cells were incubated with cyclosporine (CyA) 10 μg/mL with or without Egfl7 (100 ng/mL) or the Notch receptor activator …
Authors
Badiwala MV; Guha D; Tumiati L; Joseph J; Ghashghai A; Ross HJ; Delgado DH; Rao V
Journal
Circulation, Vol. 124, No. 11_suppl_1, pp. s197–s203
Publisher
Wolters Kluwer
Publication Date
September 13, 2011
DOI
10.1161/circulationaha.110.011734
ISSN
0009-7322
Fields of Research (FoR)
Medical Subject Headings (MeSH)
CalcineurinCalcineurin InhibitorsCalcium-Binding ProteinsCell AdhesionCells, CulturedCoronary VesselsCyclosporineEGF Family of ProteinsEndothelial Growth FactorsEndothelium, VascularHumansImmunosuppressive AgentsIntercellular Adhesion Molecule-1Intercellular Signaling Peptides and ProteinsJagged-1 ProteinMembrane ProteinsNF-kappa BNeutrophilsNitric OxideReceptors, NotchSerrate-Jagged ProteinsSignal Transduction