Conference
Mitochondrial Dysfunction is Not a Causative Factor in the Pathogenesis of Obesity
Abstract
The causal role of mitochondrial dysfunction and mtDNA mutagenesis in the etiology of obesity and type 2 diabetes remains equivocal. We revisited this controversy by measuring mtDNA copy number, protein content of mitochondrial respiratory chain subunits (COX –II and –IV) and mitochondrial COX activity in the vastus lateralis of lean and obese men (N=9/group). Obese men had significantly higher total body weight (44%) and fat mass (140%) …
Authors
Samjoo I; Safdar A; Hamadeh M; Raha S; Gregory K; Prolla T; Tarnopolsky M
Volume
24
Pagination
pp. 1045.9-1045.9
Publisher
Wiley
Publication Date
April 2010
DOI
10.1096/fasebj.24.1_supplement.1045.9
Conference proceedings
The FASEB Journal
Issue
S1
ISSN
0892-6638