Journal article
Light chain type predicts organ involvement and survival in AL amyloidosis patients receiving stem cell transplantation
Abstract
We evaluated the impact of light chain type, lambda (λ) or kappa (κ), on disease features and outcomes in patients with immunoglobulin light chain (AL) amyloidosis receiving stem cell transplant at the Mayo Clinic between October 2002 and August 2016. Patients with λ AL amyloidosis had higher rates of renal and neurological involvement (λ 69% vs κ 57%, P = .02 and λ 16% vs κ 9%, P = .03, respectively). Patients with κ AL amyloidosis had more …
Authors
Sidiqi MH; Aljama MA; Muchtar E; Buadi FK; Warsame R; Lacy MQ; Dispenzieri A; Dingli D; Leung N; Gonsalves WI
Journal
Blood Advances, Vol. 2, No. 7, pp. 769–776
Publisher
American Society of Hematology
Publication Date
April 10, 2018
DOI
10.1182/bloodadvances.2018016782
ISSN
2473-9529
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AgedFemaleHematopoietic Stem Cell TransplantationHumansImmunoglobulin Light ChainsImmunoglobulin Light-chain AmyloidosisImmunoglobulin kappa-ChainsImmunoglobulin lambda-ChainsKidney DiseasesLiver DiseasesMaleMiddle AgedPredictive Value of TestsRetrospective StudiesSurvival AnalysisTransplantation Conditioning