Angiotensin II signalling regulates skeletal muscle growth and myoblast chemotaxis

The regulatory role of angiotensin II (Ang II) in mediating skeletal muscle hypertrophy is largely unknown. We examined the impact of Ang II on myoblast chemotaxis using transwell assays. Exogenous treatment of Ang II significantly increased the migratory capacity of both C2C12 and primary myoblasts by 30 and 43% respectively, while Ang II receptor knockout myoblasts (AT1a −/− ) demonstrated a significant attenuation of basal migration (38% of …