Journal article
ABCB1 Gene Variants and Antidepressant Treatment Outcomes: A Systematic Review and Meta‐Analysis Including Results from the CAN‐BIND‐1 Study
Abstract
The P-glycoprotein efflux pump, encoded by the ABCB1 gene, has been shown to alter concentrations of various antidepressants in the brain. In this study, we conducted a systematic review and meta-analysis to investigate the association between six ABCB1 single-nucleotide polymorphisms (SNPs; rs1045642, rs2032582, rs1128503, rs2032583, rs2235015, and rs2235040) and antidepressant treatment outcomes in individuals with major depressive disorder …
Authors
Magarbeh L; Hassel C; Choi M; Islam F; Marshe VS; Zai CC; Zuberi R; Gammal RS; Men X; Scherf‐Clavel M
Journal
Clinical Pharmacology & Therapeutics, Vol. 114, No. 1, pp. 88–117
Publisher
Wiley
Publication Date
7 2023
DOI
10.1002/cpt.2854
ISSN
0009-9236