Effect of hyperoxia and hypoxia on oxygen uptake and leg blood flow during human submaximal exercise

We hypothesized that O2 delivery to exercising legs, at the onset of submaximal kicking exercise, would be maintained near control levels during hyperoxia and would be reduced during hypoxia. Alveolar oxygen uptake (VO2alv), leg oxygen uptake (VO2mus) and leg blood flow (LBF) responses were determined in normoxic (FiO2=0.21), hypoxic (FiO2=0.14) and hyperoxk (FiO2=0.70) gas breathing conditions. Eight healthy subjects performed transitions in …