Journal article
Oxytocin down‐regulates mesenteric afferent sensitivity via the enteric OTR/nNOS/NO/KATP pathway in rat
Abstract
BACKGROUND: Oxytocin plays an analgesic role in modulation of nociception and pain. Most work to date has focused on the central mechanisms of oxytocin analgesia, but little is known about whether peripheral mechanisms are also involved.
METHODS: The mesenteric afferent discharge was recorded in vitro. The expressions of oxytocin receptor (OTR) and neuronal nitric oxide synthase (nNOS) in longitudinal muscle myenteric plexus (LMMP) was …
Authors
Li J; Xue B; Han T; Huang K; Gong L; Ma X; Liu K; Cui S; Zhang M; Kunze W
Journal
Neurogastroenterology & Motility, Vol. 27, No. 1, pp. 51–62
Publisher
Wiley
Publication Date
January 2015
DOI
10.1111/nmo.12469
ISSN
1350-1925