Journal article
A Cancer Stem Cell Model for Studying Brain Metastases From Primary Lung Cancer
Abstract
BACKGROUND: Brain metastases are most common in adults with lung cancer, predicting uniformly poor patient outcome, with a median survival of only months. Despite their frequency and severity, very little is known about tumorigenesis in brain metastases.
METHODS: We applied previously developed primary solid tumor-initiating cell models to the study of brain metastases from the lung to evaluate the presence of a cancer stem cell population. …
Authors
Nolte SM; Venugopal C; McFarlane N; Morozova O; Hallett RM; O’Farrell E; Manoranjan B; Murty NK; Klurfan P; Kachur E
Journal
Journal of the National Cancer Institute, Vol. 105, No. 8, pp. 551–562
Publisher
Oxford University Press (OUP)
Publication Date
April 17, 2013
DOI
10.1093/jnci/djt022
ISSN
0027-8874