Journal article
Vascular -adrenoceptor function in hypertension and in ageing
Abstract
Functional beta-adrenoceptors (beta-AR) have been identified and characterized in blood vessels under in vivo conditions as well as in vascular smooth muscle cells (SMC) grown in culture. Agonist occupancy of beta-AR activates adenylyl cyclase (AC) via the stimulatory guanine nucleotide-binding protein (Gs) and leads to elevations in intracellular adenosine 3'5'-cyclic monophosphate levels (cAMP). Increased cAMP activates the cAMP-dependent …
Authors
Werstiuk ES; Lee RM
Journal
Canadian Journal of Physiology and Pharmacology, Vol. 78, No. 6, pp. 433–452
Publisher
Canadian Science Publishing
Publication Date
June 1, 2000
DOI
10.1139/y00-015
ISSN
0008-4212