Journal article
Safety and Efficacy of Alendronate to Treat Osteopenia in Children During Therapy for Acute Lymphoblastic Leukemia: A Retrospective Cohort Study of Sequential Outcomes
Abstract
BACKGROUND: Low bone mineral density is encountered in children with acute lymphoblastic leukemia (ALL) before, during, and after treatment. Prior experience with alendronate, an oral bisphosphonate, demonstrated high tolerability and evident clinical efficacy. However, concerns have been expressed about the long-term safety and utility of such agents in children.
PROCEDURE: Sixty-nine children with ALL received alendronate for a mean of 87 …
Authors
MacDonald P; Cranston A; Virdee M; Farncombe T; Athale U; Barr RD
Journal
Journal of Pediatric Hematology/Oncology, Vol. 45, No. 4, pp. 200–206
Publisher
Wolters Kluwer
Publication Date
May 2023
DOI
10.1097/mph.0000000000002606
ISSN
1077-4114