Journal article
Limb Immobilization Induces a Coordinate Down-Regulation of Mitochondrial and Other Metabolic Pathways in Men and Women
Abstract
Advancements in animal models and cell culture techniques have been invaluable in the elucidation of the molecular mechanisms that regulate muscle atrophy. However, few studies have examined muscle atrophy in humans using modern experimental techniques. The purpose of this study was to examine changes in global gene transcription during immobilization-induced muscle atrophy in humans and then explore the effects of the most prominent …
Authors
Abadi A; Glover EI; Isfort RJ; Raha S; Safdar A; Yasuda N; Kaczor JJ; Melov S; Hubbard A; Qu X
Journal
PLOS ONE, Vol. 4, No. 8,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0006518
ISSN
1932-6203