Journal article
Kappa-Opioid Receptor Stimulation Quickens Pathogenesis of Compulsive Checking in the Quinpirole Sensitization Model of Obsessive–Compulsive Disorder (OCD)
Abstract
Repeated injections of the D2/D3 dopamine agonist, quinpirole, induce locomotor sensitization and compulsive checking behavior in rats, a phenomenon that may constitute an animal model of obsessive- compulsive disorder (OCD). Considering that the co-joint treatment with quinpirole and the kappa opioid receptor agonist U69593 potentiates locomotor sensitization to quinpirole, the present study examined whether such co-stimulation of kappa and …
Authors
Perreault ML; Seeman P; Szechtman H
Journal
Behavioral Neuroscience, Vol. 121, No. 5, pp. 976–991
Publisher
American Psychological Association (APA)
Publication Date
10 2007
DOI
10.1037/0735-7044.121.5.976
ISSN
0735-7044
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AlgorithmsAnimalsBenzazepinesBenzeneacetamidesDomperidoneDopamine AgonistsDopamine AntagonistsHyperkinesisKineticsLigandsMaleMotor ActivityObsessive-Compulsive DisorderPyrrolidinesQuinpiroleRacloprideRatsRats, Long-EvansReceptors, Dopamine D2Receptors, Dopamine D3Receptors, Opioid, kappaStereotyped Behavior