Journal article
Obsessive-compulsive disorder: Insights from animal models
Abstract
Research with animal models of obsessive-compulsive disorder (OCD) shows the following: (1) Optogenetic studies in mice provide evidence for a plausible cause-effect relation between increased activity in cortico-basal ganglia-thalamo-cortical (CBGTC) circuits and OCD by demonstrating the induction of compulsive behavior with the experimental manipulation of the CBGTC circuit. (2) Parallel use of several animal models is a fruitful paradigm to …
Authors
Szechtman H; Ahmari SE; Beninger RJ; Eilam D; Harvey BH; Edemann-Callesen H; Winter C
Journal
Neuroscience & Biobehavioral Reviews, Vol. 76, No. Pt B, pp. 254–279
Publisher
Elsevier
Publication Date
May 2017
DOI
10.1016/j.neubiorev.2016.04.019
ISSN
0149-7634