Journal article
The Epoxy Group of Pramanicin Is Required for the Optimal Endothelium-Dependent Relaxation of Rat Aorta
Abstract
The vascular effects of a newly discovered anti-fungal agent, pramanicin (PMC), and its two analogues, PMC-A, in which the epoxy group is replaced by a - HC = CH - bond, and PMC-B, on which the diene is converted to the saturated (CH(2))(4)-derivative, respectively, were investigated in rat aorta. All three compounds caused an initial endothelial-dependent relaxation, which is prevented either by removal of endothelium or inclusion of the …
Authors
Kwan C-Y; Zhang W-B; Miller J; Harrison PHM; Kassan S; Liscombe D
Journal
Journal of Pharmacological Sciences, Vol. 92, No. 3,
Publisher
Japanese Pharmacological Society
Publication Date
2003
DOI
10.1254/jphs.92.203
ISSN
1347-8613