Journal article
Autoantibody-mediated Macrophage Dysfunction in Patients with Severe Asthma with Airway Infections.
Abstract
Rationale: Localized autoimmune responses have been reported in patients with severe eosinophilic asthma, characterized by eosinophil degranulation and airway infections. Objective: To determine the presence of autoantibodies against macrophage scavenger receptors within the airways and their effects on macrophage function and susceptibility to infection. Methods: Anti-EPX (eosinophil peroxidase), anti-MARCO (macrophage receptor with …
Authors
Son K; Miyasaki K; Salter B; Loukov D; Chon J; Zhao N; Radford K; Huang C; LaVigne N; Dvorkin-Gheva A
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 207, No. 4, pp. 427–437
Publisher
American Thoracic Society
Publication Date
February 15, 2023
DOI
10.1164/rccm.202206-1183oc
ISSN
1073-449X