Multidisciplinary Aspects of Regulatory Systems Relevant to Multiple Stressors: Aging, Xenobiotics and Radiation

Free-radical biology, which is central to the fields of radiation, aging and xenobiotics, has shifted from a paradigm highlighting damage to a paradigm emphasizing the role of free radicals in regulatory processes. A unified approach is possible since multiple stressors tend to activate a coordinated set of common mechanisms. These include antioxidant defenses, metal chelators, DNA repair systems, heat-shock proteins, xenobiotic efflux …