Journal article
miR‐4734 conditionally suppresses ER stress‐associated proinflammatory responses
Abstract
Prolonged metabolic stress can lead to severe pathologies. In metabolically challenged primary fibroblasts, we assigned a novel role for the poorly characterized miR-4734 in restricting ATF4 and IRE1-mediated upregulation of a set of proinflammatory cytokines and endoplasmic reticulum stress-associated genes. Conversely, inhibition of this miRNA augmented the expression of those genes. Mechanistically, miR-4734 was found to restrict the …
Authors
Michael D; Feldmesser E; Gonen C; Furth N; Maman A; Heyman O; Argoetti A; Tofield A; Baichman‐Kass A; Ben‐Dov A
Journal
FEBS Letters, Vol. 597, No. 9, pp. 1233–1245
Publisher
Wiley
Publication Date
5 2023
DOI
10.1002/1873-3468.14548
ISSN
0014-5793